Nicotine, Impulsivity And Attentional Performance: Taking A Step Back Into The Future

Nicotine, Impulsivity And Attentional Performance
Nicotine dependence, reward, impulsivity and attentional performance: Taking a step back into the future

"High impulsivity levels may be a risk factor for nicotine dependence, leading to its initiation and maintenance. Further, numerous studies have shown that ?-aminobutyric acid B (GABAB) receptor antagonists show cognitive enhancing effects. Little is known about the effects of GABAB receptor agonists or positive allosteric modulators (PAMs) in cognitive processes (e.g., attentional performance) and impulsivity/compulsivity. GABAB receptor PAMs may be potentially improved therapeutic compounds for the treatment of disorders, such as drug dependence, or cognitive impairment, than GABAB receptor agonists due to fewer adverse side-effects. In different experiments, BHF177 , a GABAB receptor PAM , decreased both the reinforcing and motivational effects of nicotine without affecting motivation for natural reinforcers, such as food, using the nicotine self-administration fixed-ratio 5 and progressive ratio procedures, respectively, both in rats from the general population as well as in high and low impulsive rats in a similar manner. Interestingly, BHF177 had a larger magnitude of effect in low impulsive rats at the highest dose tested. High/low impulsivity animals were selected based on the poor inhibitory control aspect of impulsivity, as assessed in the 5-choice serial reaction time task (5-CSRTT). Further, BHF177 dose-dependently and selectively blocked cue-induced reinstatement of nicotine seeking, a putative animal model of relapse in humans, and not food seeking, while chronic treatment with BHF177 decreased nicotine self-administration with only small tolerance developed in the general population. Further, BHF177 showed significantly fewer adverse effects than the GABAB receptor agonist CGP44532 in the 5-CSRTT. Thus, BHF177 , or other similar GABAB receptor PAMs, could be useful therapeutics for the treatment of different aspects of nicotine dependence..."



If you wanna know more about what we are about, make sure to visit our site simply at and get your Smokin’ Sweets!

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top